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Mixed Conditions: (Tremont et al., 2011; n = 200 (50 Healthy controls (HC), mean age = 70.28 (7.88), female = 72%; 100 w/Mild Cognitive Impairment (MCI), mean age = 72.92 (6.70), female = 57%; 50 w/Alzheimer¡¯s Disease (AD), mean age = 74.08, female = 58%; testing w/MCAS an average of 18.91 (15.20) days following their office visit)

• Youden index approach estimated optimal pairs cutoff scores for the 3-class classification problem:
  • MCI region boundaries (42.5, 52.5)
  • Scores < 42.5 classified as AD (sensitivity 86%; specificity 77%)
  • Scores > 52.5 classified as HC (sensitivity 86%; specificity 78%)

Mixed Conditions: (Knopman et al., 2000, n = 228 (99 mild to moderately demented nursing home residents w/diagnosis of dementia, female = 70%, mean age = 82.4 (9.4) years and 129 community-dwelling senior citizens, female = 71%, mean age = 73.8 (6.4) years)

Means and Std. Deviations (SD) of Minnesota Cognitive Acuity Screen by Subtest*

*Uncorrected for age and education; all group differences significant at p < 0.01

Mixed Conditions: (Tremont et al., 2011)

Mean Minnesota Cognitive Acuity Screen Scores by Group^a

MCI = mild cognitive impairment, AD = Alzheimer¡¯s disease, SD = standard deviation

^aMeans sharing the same subscript are not significantly different from each other (Fisher¡¯s least significant difference, p < 0.05), except digit span (MCI = Controls) and naming (no differences between the groups).

Mixed Conditions: (Margolis et al., 2018; n = 146 (HC = 37, MCI = 70, AD = 39), age range = 56-86, initial baseline MCAS testing with follow-up over eight years for establishing dates of starting homecare, institutionalization, and death)

• Mean MCAS total score = 47.03 (9.08)
• Median MCAS score = 47.5 

Predictive validity:

Mild Cognitive Impairment: (Tremont et al., 2016; n = 61, mean age = 73.3 (6.0), age range = 60-84, established diagnosis of amnestic MCI)

Cognitive Decline

• The MCAS total score at baseline was not predictive of the rate of cognitive decline in participants with MCI after controlling for time since study entry (p = 0.21, see Table below)
• The computation subscale was the only nominally significant predictor of cognitive decline (p = 0.01, see Table below), with DRS-2 total score at follow-up decreasing by 1.56 points per 1-point decrease in baseline computation score

Effects of Baseline Minnesota Cognitive Acuity Screen and its Subscales on Annual Dementia Rating Scale-2 Change in Individuals with Mild Cognitive Impairment*

*All regression coefficients were adjusted for time since study entry, modeled in the logarithmic scale

Functional Decline

• The MCAS total score at baseline was significantly associated with slower functional decline in participants with MCI after controlling for time since study entry (p = 0.02, see Table below). Increases in baseline MCAS total scores from 43 to 50 points were associated with 0.59-point decreases in Clinical Dementia Rating Scale-Sum of Box (CDR-SOB) scores at follow-up.
• The delayed word recall (DWR) subtest was a very significant (p = 0.001, see Table below) predictor of functional decline of the individual MCAS subtests, with each 1-point increase in baseline DWR score associated with 0.22-point decreases in CDR-SOB scores at follow-up.  
• The computation subscale was only nominally associated with functional decline (p = 0.01, see Table below), with 1-point increases in baseline computation scores associated with 0.28-point decreases in CDR-SOB scores at follow-up.

Effects of Baseline Minnesota Cognitive Acuity Screen and its Subscales on Annual Clinical Dementia Rating Scale¡ªSum of Box Score Change in Individuals with Mild Cognitive Impairment*

*All regression coefficients were adjusted for time since study entry, modeled in the logarithmic scale

• Participants with MCI had a 46% lower risk of dementia at any given follow-up time if their MCAS total score was in the third rather than the first sample quartile (hazard ratio = 0.54)